| 摘要 |
Compounds of Formula (I) have been found to be effective transdermal and transmucosal penetration enhancers. A composition of the invention therefore comprises a compound of Formula (I) or a pharmaceutically acceptable salt thereof and a pharmacologically active agent wherein: X is O or CH - R5 R5 is branched or straight C5-C14 alkyl, especially 2-propylpentyl; and when X is O then R1, R2, R3 and R4 each independently is H or at most two of them being branched or straight C4 - C16 alkyl, the remaining being H, A is (CH2)2-6 R6 is OH; and when X is CH - R5 then R1, R2, R3 and R4 is H; A is (CH)2-6 or CO(CH2)6-14; R6 is CH3 or OH; and N in formula (I) optionally being quaternized, including racemic and enantiomeric forms. |
