METHODS OF IDENTIFYING MODULATORS OF AN EHD POLYPEPTIDE
摘要
The invention relates to a method of identifying a modulator of an EHD family polypeptide, said method comprising (i) providing a first and second sample of an EHD polypeptide; (ii) contacting said first sample with a candidate modulator; (iii) contacting said first and second samples with ATP; and (iv) monitoring ATP hydrolysis in said first and second samples, wherein a difference between the ATP hydrolysis in said first and second samples identifies said candidate modulator as a modulator of an EHD family polypeptide. The invention also relates to methods of modelling molecules and to various EHD mutant polypeptides.
申请公布号
WO2009044156(A3)
申请公布日期
2009.07.23
申请号
WO2008GB03355
申请日期
2008.10.01
申请人
MEDICAL RESEARCH COUNCIL;MCMAHON, HARVEY;DOHERTY, GARY;LUNDMARK, RICHARD;DAUMKE, OLI
发明人
MCMAHON, HARVEY;DOHERTY, GARY;LUNDMARK, RICHARD;DAUMKE, OLI