| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a more practically advantageous enzyme usable as a reagent for measuring blood glucose than the known enzymes used as blood glucose sensors. <P>SOLUTION: The modified flavin-adenine-dinucleotide-dependent glucose dehydrogenase (FADGDH) has an improved thermal stability compared to a wild-type FADGDH, which is preferably derived from a eukaryote, more preferably derived from a filamentous fungus, still more preferably derived from a fungus belonging to the genus Aspergillus. The modified FADGDH has a primary structure having the substitution, deletion, insertion or addition of at least one amino acid residue in the FADGDH having specific amino acid sequence. <P>COPYRIGHT: (C)2009,JPO&INPIT |
