PROSTATE CANCER SUSCEPTIBILITY SCREENING

摘要

A panel of prostate cancer susceptibility markers allows screening to identify individuals at high risk of developing prostate cancer. Such individuals can be offered closer clinical follow up and management to ensure timely diagnosis and intervention. A number of the single nucleotide polymorphisms (SNP's) have been found to be linked to sites/genes that are expected to play functional/causative roles in prostate cancer. The most highly associated SNP (rs 10993994) is 2bp upstream of the transcriptional start site of the MSMB gene. The MSMB gene encodes PSP94 which is an immunoglobulin binding factor that is produced by prostate epithelial cells and secreted into the seminal fluid. It has been reported that loss of PSP94 is associated with tumour recurrence in patients following prostatectomy. The second most significant association is for the SNP rs2735839 which is located between the kallikrein 2 and 3 genes. These genes have also been linked to prostate cancer and proposed as possible screening markers. Further SNPs are significantly associated with prostate cancer susceptibility if individuals.