METHODS FOR TREATING INDUCED CELLULAR PROLIFERATIVE DISORDERS
摘要
Methods are provided for treating a subject with a cellular proliferative disorder that include administering to the subject a therapeutically effective amount of a JAK2 inhibitor and a therapeutically effective amount of a TNF-alpha inhibitor. In addition, methods are provided herein for determining if a subject with a cellular proliferative disorder would benefit from treatment with an agent that inhibits tumor necrosis factor (TNF)-alpha. Methods are also provided for identifying an agent of use in treating a subject with a cellular proliferative disorder or with a predisposition for cellular proliferative disorder. The methods include contacting an isolated cell expressing an activating mutation in the JAK2 protein with a test agent, and detecting the amount of tumor necrosis factor (TNF)-alpha produced by the cell.
申请公布号
WO2009073575(A3)
申请公布日期
2009.07.23
申请号
WO2008US85073
申请日期
2008.11.28
申请人
OREGON HEALTH & SCIENCE UNIVERSITY;BUMM, THOMAS, G.P.;DEININGER, MICHAEL, W.N.