| 发明名称 |
C4'-SUBSTITUTED - DNA NUCLEOTIDE GAPMER OLIGONUCLEOTIDES |
| 摘要 |
<p>The present invention relates to gapmer antisense oligonucleotides which contain non bicyclic 4'modified nucleotide analogues, such as 4'hydroxymethyl DNA, within the central gap region which are capable of recruiting RNAseH when formed in a duplex with a target RNA sequence.</p> |
| 申请公布号 |
WO2009090182(A1) |
申请公布日期 |
2009.07.23 |
| 申请号 |
WO2009EP50349 |
申请日期 |
2009.01.14 |
| 申请人 |
SANTARIS PHARMA A/S;WENGEL, JESPER |
发明人 |
WENGEL, JESPER |
| 分类号 |
C07H21/00;C12N15/11;C12N15/113 |
主分类号 |
C07H21/00 |
| 代理机构 |
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