发明名称 |
RNA ANTAGONIST COMPOUNDS FOR THE MODULATION OF MCL-1 |
摘要 |
Oligonucleotides directed against the Mcl-1 gene are developed for modulating the expression of Mcl-1 protein. The compositions comprise oligonucleotides, particularly antisense oligonucleotides, targeted to nucleic acids encoding Mcl-1. Methods of using these compounds for modulation of Mcl-1 expression and for the treatment of diseases associated with over expression of Mcl-1 are provided. Examples of such diseases include cancer and systemic mastocytosis. |
申请公布号 |
WO2009071680(A3) |
申请公布日期 |
2009.07.23 |
申请号 |
WO2008EP66920 |
申请日期 |
2008.12.05 |
申请人 |
SANTARIS PHARMA A/S;HANSEN, JENS BO;HOEG, ANJA MOELHART |
发明人 |
HANSEN, JENS BO;HOEG, ANJA MOELHART |
分类号 |
A61K38/00;C12N15/113 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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