PEPTIDES FOR THE SPECIFIC BINDING AND REGULATION OF PROTEIN TARGETS

摘要

The present invention relates to peptides comprising an amino acid sequence motif selected from an amino acid sequence motif of the general formula (E/D) YxFxx(E/D) (including the more specific formula EYxFxxD); LQxLDxVL; N/K/RxxYxxHP; NxxEYxxK; YAxxI; TxPxY; FxDL; and (R/K)(V/I/L)xF (including the more specific formula RVxF). Moreover, the present invention relates to a polynucleotide encoding said peptide, a vector comprising said polynucleotide, a host cell comprising the peptide, the vector or the polynucleotide, an antibody specifically recognizing the peptide or an array comprising the peptide, the polynucleotide, the host cell or the antibody. Moreover, encompassed by the invention are pharmaceutical compositions, which comprise the peptide, the polynucleotide, the vector, the host cell or the antibody and the use of such compositions for the treatment of various diseases. Finally, the present invention relates to methods for identifying compounds, which specifically block interactions of the tumor protein p53 (TP53); SMAD-SMAD interactions; interactions of histone deacetylases (HDACs), protein tyrosine phosphatase, non-receptor type 11 (PTPNI11), RNA binding protein with multiple splicing (RBPMS), inhibitor of growth family, member 5 (ING5), cyclin A1 (CCNA1) and/or protein phosphatase 1 (PPP1CA (B,C)).