发明名称 |
Poly(Ethylene Glycol) Derivatives with Proximal Reactive Groups |
摘要 |
An activated, substantially water-soluble poly(ethylene glycol) is provided having of a linear or branched poly(ethylene glycol) backbone and at least one terminus linked to the backbone through a hydrolytically stable linkage, wherein the terminus is branched and has proximal reactive groups. The free reactive groups are capable of reacting with active moieties in a biologically active agent such as a protein or peptide thus forming conjugates between the activated (polyethylene glycol) and the biologically active agent.
|
申请公布号 |
US2009186984(A1) |
申请公布日期 |
2009.07.23 |
申请号 |
US20090410438 |
申请日期 |
2009.03.24 |
申请人 |
NEKTAR THERAPEUTICS AL, CORPORATION |
发明人 |
HARRIS J. MILTON;KOZLOWSKI ANTONI |
分类号 |
C08G65/333;A61K47/48;C08F26/10;C08F216/06;C08G65/32;C08G65/329 |
主分类号 |
C08G65/333 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|