发明名称 |
Combination therapy of beta-glycolipids and antibodies for the treatment of immune-related disorders |
摘要 |
The present invention relates to a combination therapy for the treatment of immune-related disorders. More particularly, the invention relates to oral or mucosal synergistic compositions combining beta-glycolipids, preferably,β-glycosphin-golipids with immunoglobulin molecules specific for at least one antigen derived from a component of the immune system, specifically an anti-CD3 antibody. The invention further provides methods kits and uses of the combined compositions of the invention for immune-modulation and thereby for the treatment of immune-related disorders. In a preferred embodiment, anti-CD3 antibody (OKT3) is orally administered in combination withβ-glucosylceramide (also known as glycocerebroside) in an animal model of type 2 diabetes. |
申请公布号 |
AU2009205265(A1) |
申请公布日期 |
2009.07.23 |
申请号 |
AU20090205265 |
申请日期 |
2009.01.18 |
申请人 |
HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LTD.;THE BRIGHAM AND WOMEN'S HOSPITAL INC. |
发明人 |
HOWARD L. WEINER;YARON ILAN |
分类号 |
C07K16/28;A61K31/70;A61K39/39;A61K45/06;A61P3/10;A61P37/02 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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