发明名称 |
SPECIFIC INHIBITORS OF NFAT ACTIVATION BY CALCINEURIN AND THEIR USE IN TREATING IMMUNE-RELATED DISEASES |
摘要 |
Isolated peptide fragments of the conserved regulatory domain of NFAT protein capable of inhibiting protein-protein interaction between calcineurin and NFAT, or a biologically active analog thereof are described. Isolated polynucleotides and gene therapy vectors encoding such peptide fragments are also described. In addition, methods for treating immune-related diseases or conditions and methods for high throughput screening of candidate agents are described. Pharmaceutical compositions are also provided.
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申请公布号 |
US2009186422(A1) |
申请公布日期 |
2009.07.23 |
申请号 |
US20080260049 |
申请日期 |
2008.10.28 |
申请人 |
THE CBR INSTITUTE FOR BIOMEDICAL RESEARCH, INC., A MASSACHUSETTS CORPORATION |
发明人 |
HOGAN PATRICK G.;RAO ANJANA;ARAMBURU JOSE |
分类号 |
G01N33/566;A61K;A61K38/00;C07K5/103;C07K7/00;C07K14/00 |
主分类号 |
G01N33/566 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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