发明名称 |
RANTES LEVELS AS A DIAGNOSTIC AND THERAPEUTIC FOR ACUTE GRAFT VERSUS HOST DISEASE |
摘要 |
Disclosed herein are methods for determining the likelihood of a subject to develop Acute graft versus host disease (aGVHD) upon receiving myeloablative allogeneic hematopoietic stem cell transplantation (HSCT). One such method comprises assaying for baseline plasma concentration of RANTES in a sample obtained from the subject, and comparing the baseline plasma concentration of RANTES to a predetermined level. The method may further comprise assaying for day 7 plasma concentration of RANTES in sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for day 7 plasma concentration of RANTES in a sample obtained from the subject, and comparing the day 7 plasma concentration of RANTES to a predetermined level. Another such method comprises assaying for donor plasma concentration of RANTES in a sample obtained from a donor of the hemtopoietic stem cells, and comparing the donor plasma concentration of RANTES to a predetermined level, wherein a donor plasma concentration of RANTES less than the predetermined level indicates a likelihood of the subject to develop aGVHD upon receiving myeloablative allogeneic HSCT from that donor. Other methods include assaying for day 0, or for day 7, plasma concentration of MCP-1 in a sample obtained from the subject, and comparing the day 0 or day 7, plasma concentration of MCP-1 to a predetermined level.
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申请公布号 |
WO2009062160(A9) |
申请公布日期 |
2009.07.23 |
申请号 |
WO2008US83001 |
申请日期 |
2008.11.10 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;DANA-FARBER CANCER INSTITUTE, INC.;LEVY, OFER;GUINAN, EVA;SUTER, EUGENIE;KALISH, LESLIE |
发明人 |
LEVY, OFER;GUINAN, EVA;SUTER, EUGENIE;KALISH, LESLIE |
分类号 |
G01N33/574;G01N33/48;G01N33/53;G01N33/68 |
主分类号 |
G01N33/574 |
代理机构 |
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地址 |
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