发明名称 |
Method of identifying a modulator of a voltage-gated sodium channel using cells expressing Nav1.8 and p11 |
摘要 |
The present invention provides a method of identifying a modulator of a voltage gated sodium channel (VGSC), which method comprises bringing into contact a VGSC, a p11 peptide and a test compound under conditions where the VGSC and the p11 peptide are capable of forming a complex in the absence of the test compound; and measuring an activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC. Compounds identified in such screening methods are proposed for use in the treatment of VGSC-related conditions, for example in the treatment or prevention of pain. Also provided are methods of enhancing the functional expression of a voltage gated sodium channel (VGSC) in a cell comprising the step of increasing the level of p11 in the cell.
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申请公布号 |
US7563586(B2) |
申请公布日期 |
2009.07.21 |
申请号 |
US20040487337 |
申请日期 |
2004.07.13 |
申请人 |
UNIVERSITY COLLEGE LONDON |
发明人 |
OKUSE KENJI;BAKER MARK;POON LOUISA;WOOD JOHN NICHOLAS;MALIK-HALL MISBAH |
分类号 |
G01N33/50;G01N33/566;A61K31/7088;A61K38/00;A61K39/395;A61K45/00;A61K48/00;A61P25/02;A61P25/04;A61P29/00;A61P29/02;A61P43/00;C07K14/47;C07K14/705;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N5/16;C12N5/18;C12N5/22;C12N15/09;C12Q1/02;G01N33/15;G01N33/68 |
主分类号 |
G01N33/50 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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