| 摘要 |
THE PRESENT INVENTION RELATES TO NOVEL COMPOUNDS OF FORMULA (I)(FORMULA I)WHEREIN ~ ---- REPRESENT A SINGLE OR A DOUBLE BOND;@~ R REPRESENTS A RADICAL SELECTED FROM :(FORMULA i)(FORMULA ii)(FORMULA iii)AND (FORMULA iv)IN WHICH R1 IS HALOGEN, CYANO, C1-4 ALKYL, C1-4 ALKOXY, TRIFLUOROMETHYL OR TRIFLUOROMETHOXY AND p IS ZERO OR AN INTEGER FROM 1 TO 3;@~ R2 REPRESENTS HYDROGEN OR C1-4 ALKYL;@~ R3 REPRESENTS HYDROGEN, HYDROXY OR C1-4 ALKYL;@~ R4 REPRESENTS HYDROGEN OR R4 TOGETHER WITH R3 REPRESENTS =O OR =CH2;@~ R5 REPRESENTS PHENYL, NAPHTHYL, A 9 TO 10 MEMBERED FUSED BICYCLIC HETEROCYCLIC GROUP OR A 5 OR 6 MEMBERED HETEROARYL GROUP, WHEREIN SAID GROUPS ARE OPTIONALLY SUBSTITUTED BY 1 TO 3 GROUPS INDEPENDENTLY SELECTED FROM TRIFLUOROMETHYL, C1-4A LKYL, HYDROXY, CYANO, C1-4 ALKOXY, TRIFLUOROMETHOXY, HALOGEN OR S(O)qC1-4 ALKYL;@~ R6 AND R7 INDEPENDENTLY REPRESENT HYDROGEN, CYANO, C1-4 ALKYL;@~ R8 IS (CH2)rR10;@~ R9 REPRESENTS HYDROGEN, HALOGEN, C3-7 CYCLOALKYL, HYDROXY, NITRO, CYANO OR C1-4 ALKYL OPTIONALLY SUBSTITUTED BY ONE OR TWO GROUPS SELECTED FROM GALOGEN, CYANO, HYDROXY OR C1-4 ALKOXY;@~ R10 REPRESENT HYDROGEN OR C3-7 CYCLOALKYL;@~ n REPRESENT 1 OR 2;@~q IS 0, 1 OR 2;@~ r IS 0 OR AN INTEGER FROM 1 TO 4;@OR A PHARMACEUTICALLY ACCEPTABLE SALT OR A SOLVATE THEREOF, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CONDITIONS MEDIATED BY TACKYKININS AND/OR BY SELECTIVE INHIBITION OF THE SEROTONIN REUPTAKE TRANSPORTER PROTEIN.
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