发明名称 Selectable genetic marker for use in pasteurellaceae species
摘要 The present invention provides a nucleic acid encoding nicotinamide phosphoribosyltransferase (NadV) from a V-factor independent bacterium and provides methods for using the gene as a selection marker for constructing recombinant bacteria from V-factor dependent bacteria. The method is an improvement over methods which rely on nucleic acids which confer antibiotic resistance for constructing recombinant bacteria. Methods for constructing attenuated recombinant Actinobacillus pleuropneumoniae using the selection method of the present invention are also provided.
申请公布号 US2009098654(A1) 申请公布日期 2009.04.16
申请号 US20080080668 申请日期 2008.04.04
申请人 BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY 发明人 MULKS MARTHA H.;MARTIN PAUL R.;SHEA ROBIN J.
分类号 C12N15/75;A61K39/00;C12N1/21;C12N15/31;C12N15/54;C12N15/74 主分类号 C12N15/75
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