发明名称 |
REAGENTS FOR THE DETECTION OF PROTEIN PHOSPHORYLATION IN LEUKEMIA SIGNALING PATHWAYS |
摘要 |
The invention discloses 424 novel phosphorylation sites identified in signal transduction proteins and pathways underlying human Leukemia, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Cytoskeletal proteins, Cellular Metabolism enzymes, G Protein/GTPase Activating/Guanine Nucleotide Exchange Factor proteins, Immunoglobulin Superfamily proteins, Inhibitor proteins, Lipid Kinases, Nuclear DNA Repair/RNA Binding/Transcription proteins, Serine/Threonine Protein Kinases, Tyrosine Kinases, Protein Phosphatases, and Translation/Transporter proteins. |
申请公布号 |
WO2006086111(A3) |
申请公布日期 |
2009.04.16 |
申请号 |
WO2006US00979 |
申请日期 |
2006.01.12 |
申请人 |
CELL SIGNALING TECHNOLOGY, INC.;GOSS, VALERIE;MORITZ, ALBRECHT;GU, TING-LEI;LEE, KIMBERLY;POLAKIEWICZ, ROBERTO |
发明人 |
GOSS, VALERIE;MORITZ, ALBRECHT;GU, TING-LEI;LEE, KIMBERLY;POLAKIEWICZ, ROBERTO |
分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
代理机构 |
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