INHIBITORS FOR EXTRACELLULAR SIGNAL-REGULATED KINASE DOCKING DOMAINS AND USES THEREFOR
摘要
Provided herein are compounds and methods of using compounds that selectively inhibit binding to one or more docking domain regions of an extracellular signal- recognition kinase to inhibit in a cell having an extracellular signal-regulated kinase activity. Such methods may be used to inhibit cell proliferation of a neoplastic cell, to treat a cancer and further may be used in conjunction with administration of an anticancer drug at a reduced dosage to treat a cancer with a concomitant reduction in toxicity to an individual receiving the treatment. Also provided is a method to design and screen for compounds to inhibit binding within the extracellular signal-regulated kinase docking domain region, using at least in part computer-aided drug design modeling.
申请公布号
WO2006105237(A3)
申请公布日期
2009.04.16
申请号
WO2006US11536
申请日期
2006.03.29
申请人
THE UNIVERSITY OF MARYLAND, BALTIMORE;SHAPIRO, PAUL;MACKERREL, ALEXANDER