GENETICALLY ENGINEERED BLOOD COAGULATION FACTOR X HAVING NO SUGAR CHAIN, AND METHOD FOR PRODUCTION THEREOF

摘要

Disclosed is a highly activated blood coagulation factor X (referred to as "FX", hereinbelow). Specifically disclosed are: a method for efficiently producing a genetically engineered double-stranded FX, which is characterized by inhibiting the addition of a sugar chain to an amino acid sequence that is essential for the addition of a sugar chain to the FX, thereby expressing a genetically engineered FX having no sugar chain; and a genetically engineered FX having no sugar chain, which is produced by the method.