NANOPARTICLES AND DENDRITIC-POLYMER-BASED HYDROGELS COMPRISING THEM

摘要

One aspect of the present invention relates to compositions comprising polymers and nanoparticles that form hydrogels useful as lens replacement materials, lens substitute materials, corneal inlays, and intraocular lenses. The hydrogels of the invention can be formed using a polyacrylate, silicone, or dendritic macromolecule. In certain instances, the hydrogels of the invention comprise nanoparticles ranging in diameter from about 0.1 nm to about 100 nm. The nanoparticles are generally dispersed throughout the hydrogel and may be covalently or noncovalently crosslinked. The nanoparticles may be made of a metal, metal oxide, or ceramic. In certain instances, the nanoparticles comprise a ceramic core coated with a layer of silica. Another aspect of the present invention relates to a method of forming a lens composition comprising treating a mixture of a polymerizable dendrimeric compound and nanoparticles with a polymerization agent. Another aspect of the present invention relates to a nanoparticle comprising a core coated with a layer of silica. In certain instances, the core is made of a metal, metal oxide, or ceramic. Another aspect of the invention relates to a kit for forming a lens comprising a polymerizable dendrimeric compound, nanoparticles, and a system for delivering the dendrimeric compound and nanoparticles to the lens bag of a patient.