发明名称 |
COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE |
摘要 |
Compounds and pharmaceutical compositions are contemplated that inhibit N-acyl-ethanolamine-hydrolyzing acid amidase (NAAA) to so increase the concentration of the substrate of NAAA, palmitoylethanolamide (PEA). NAAA inhibition is contemplated to be effective to alleviate conditions associated with a reduced concentration of PEA. Among other uses, various NAAA inhibitors are especially contemplated as therapeutic agents in the treatment of inflammatory diseases. |
申请公布号 |
CA2711957(A1) |
申请公布日期 |
2009.04.16 |
申请号 |
CA20082711957 |
申请日期 |
2008.10.10 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
PIOMELLI, DANIELE;TARZIA, GIORGIO;MOR, MARCO;DURANTI, ANDREA;TONTINI, ANDREA |
分类号 |
A61K8/00;A61K8/18;A61Q5/00 |
主分类号 |
A61K8/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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