[0068] The invention relates to compositions and methods for modulating Nurrl expression in a cell, including a cell in a subject. Somatic knock-outs of Nurrl in the adult rat midbrain were performed using viral-delivered ribozymes, and over expression of Nurrl in the adult rat brain was achieved using a recombinant Adeno-Associated Virus (AAV) vector encoding Nurrl.
申请公布号
WO2008130949(A3)
申请公布日期
2009.04.16
申请号
WO2008US60392
申请日期
2008.04.16
申请人
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.;BURGER, CORINNA;ANDRES-COKE, MARIA, ESTELA;FUENTEALBA-EVANS, JOSE, ANTONIO
发明人
BURGER, CORINNA;ANDRES-COKE, MARIA, ESTELA;FUENTEALBA-EVANS, JOSE, ANTONIO