FRACTION OF MELISSA LEAF EXTRACT HAVING ANGIOGENESIS AND MMP INHIBITORY ACTIVITIES, AND COMPOSITION COMPRISING THE SAME

摘要

The present invention relates to an ethyl acetate fraction of Melissa leaf having excellent an- giogenesis and MMP inhibitory activities, and a composition comprising the same. In particular, the ethyl acetate fraction of Melissa leaf is characterized that Melissa leaf is extracted with 50-100% C1-C6 alcohol, and concentrated, and then the concentrated alcohol extract is suspended in water, and fractionated with ethyl acetate, and dried to obtain the ethyl acetate fraction of Melissa leaf. The ethyl acetate fraction of Melissa leaf of the present invention has strong and excellent anti- angiogenic and MMP inhibitory activities. Therefore, the composition comprising the ethyl acetate fraction of Melissa leaf of the present invention can be used as an agent for the treatment or prevention of angiogenesis -related diseases and MMP-mediated diseases.