METHOD FOR PRODUCING PTERIDINE COMPOUND AND METHOD FOR PRODUCING L-BIOPTERIN

摘要

Disclosed is a method which enables to commercially advantageously produce a pteridine compound with high yield. Specifically disclosed is a method for producing a pteridine compound represented by the general formula (3) below, which is characterized in that an optically active epoxy aldehyde compound represented by the general formula (1) below and a pyrimidine compound represented by the general formula (2) below are condensed in a polar solvent in the presence of an acid having a pKa of not more than 4.5, and then the resulting is subjected to oxidation. (In the formulae below, R1 represents a protecting group of a hydroxy group, and R2 represents a hydrogen atom or a protecting group of a hydroxy group.)