发明名称 |
METHOD FOR THE PREPARATION OF MONTELUKAST ACID IN IONIC LIQUID MEDIUM |
摘要 |
The present invention relates to a method for preparing Montelukast acid or its sodium salt by reacting a thiol compound with a Montelukast intermediate in the presence of a base in a medium comprising an ionic liquid compound. In accordance with the inventive method, highly pure Montelukast acid or its sodium salt, which is advantageously used as a raw material in the preparation of Montelukast, a leukotriene antagonist, can be easily prepared in a high yield.
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申请公布号 |
CA2701912(A1) |
申请公布日期 |
2009.04.16 |
申请号 |
CA20082701912 |
申请日期 |
2008.10.01 |
申请人 |
HANMI PHARM. CO., LTD. |
发明人 |
PARK, CHUL-HYUN;PARK, EUN-JU;KIM, CHOONG-HAHN;JANG, SUK MAN;LIM, EUN JUNG;CHANG, YOUNG KIL;LEE, GWAN SUN;LEE, JAEHEON |
分类号 |
C07D215/18 |
主分类号 |
C07D215/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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