发明名称 |
COMPOUNDS FOR HEDGEHOG PATHWAY BLOCKADE IN PROLIFERATIVE DISORDERS, INCLUDING HEMATOPOIETIC MALIGNANCIES |
摘要 |
<p>Elevated Hedgehog (Hh) pathway activity, including ligand stimulated Hh pathway activity, was detected in hematopoietic malignancy cells, and determined to be associated with growth and proliferation of the malignancy cells. Accordingly, methods are provided for treating a hematopoietic cell malignancy associated with elevated Hh pathway activity by reducing or inhibiting the Hh pathway activity. Also provided are methods of determining the responsiveness of a hematopoietic cell malignancy to treatment with an Hh pathway antagonist.</p> |
申请公布号 |
WO2009049258(A1) |
申请公布日期 |
2009.04.16 |
申请号 |
WO2008US79647 |
申请日期 |
2008.10.10 |
申请人 |
THE JOHNS HOPKINS UNIVERSITY;THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;BEACHY, PHILIP, ARDEN;KIM, JYNHO |
发明人 |
BEACHY, PHILIP, ARDEN;KIM, JYNHO |
分类号 |
A61K31/395 |
主分类号 |
A61K31/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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