发明名称 |
ANTIBODIES AGAINST FLAGELLIN AND USES THEREOF |
摘要 |
The present invention provides a novel class of monoclonal antibodies which have a high affinity, broad spectrum neutralizing reactivity to flagellin from various Gram-negative bacteria including, but not limited to, E. coli, Salmonella, Serratia, Proteus, Enterobacter, Citrobacter, Campylobacter and Pseudomonas. The present invention further provides methods of treating inflammatory bowel disease (IBD) and methods of treating enterobacterial infections using anti-flagellin antibodies in humans, other animals and birds.
|
申请公布号 |
WO2009033013(A4) |
申请公布日期 |
2009.04.16 |
申请号 |
WO2008US75387 |
申请日期 |
2008.09.05 |
申请人 |
RACHAMIM, NURIT;SALZMAN, ANDREW, L.;MURTHY, KANNEGANTI |
发明人 |
RACHAMIM, NURIT;SALZMAN, ANDREW, L.;MURTHY, KANNEGANTI |
分类号 |
C07K16/00;C07H21/04;C12N5/06 |
主分类号 |
C07K16/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|