发明名称 |
Mutant F. turlarensis strain and uses thereof |
摘要 |
A mutant strain of Francisella tularensis has attenuated virulence and has a mutation in the gene coding for a putative peroxynitrite resistance protein A (prpA) which prevents normal function of the protein. The mutant is useful as a vaccine against type A and B virulent strains of F. tularensis, and is produced by obtaining a virulent F. tularensis strain and mutating the gene, FTT0918, that codes for prpA.
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申请公布号 |
US2009098163(A1) |
申请公布日期 |
2009.04.16 |
申请号 |
US20060918648 |
申请日期 |
2006.04.19 |
申请人 |
SJOSTEDT ANDERS;CONLAN JOSEPH WAYNE |
发明人 |
SJOSTEDT ANDERS;CONLAN JOSEPH WAYNE |
分类号 |
A61K39/02;C12N1/20;C12Q1/02;C12Q1/68 |
主分类号 |
A61K39/02 |
代理机构 |
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代理人 |
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地址 |
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