| 摘要 |
A series of p105-based NF-kappaB super repressors, designated p-105(sr), have been designed. The p105(sr), no longer generates p50 and undergoes signal-induced degradation, effectively inhibiting all NF-kappaB activities. Additionally, p105(sr) significantly enhances tumor necrosis factor alpha (TNF-alpha)-mediated killing of MT1/2 skin papilloma cells when p50 homodimer activity is elevated. p105(sr) is an effective NF-kappaB super repressor with a broader range than other currently available IkBalpha super repressors. The novel repressor can be used in cells where a noncanical NF-kappaB activity is dominant or multiple NF-kappaB activities are activated.
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