MULTIFUNCTIONAL TITANIUM SURFACES FOR BONE INTEGRATION

摘要

The process for the preparation of a prosthetic device or a medical implant comprising titanium or titanium alloy, through a surface modification treatment in order to make bioactive the surface of titanium or titanium alloy, comprising the steps of: a) an acid attack for the removal of native oxide present on said the surface; and b) surface controlled oxidation in an hydrogen peroxide solution in order to expose hydroxyl groups bound on the surface; the so obtained surface, bioactive from the inorganic point of view, could be further modified in order to make it bioactive also from the biological point of view by functionalization of the surface with proteins from extracellular matrix or enzymes. This process includes surface activation with trifluoroethanesulfonyl chloride and subsequent incubation of the activated surface into a solution of the biomolecule in order to obtain a covalent grafting.