发明名称 |
PROCESS FOR THE PREPARATION OF PERHYDROISOINDOLE DERIVATIVE |
摘要 |
The present invention relates to a novel, efficient and industrially advantageous process for preparing perhydroisoindole derivative, particularly (S)-mitiglinide of formula (I): and pharmaceutically acceptable salts thereof. Further, it relates to novel amide intermediates of formula (VI), including salts, solvates, hydrates, polymorphs, isomers and racemic mixtures thereof useful in the process of present invention. Formula (VI): wherein R is selected from straight chain or branched C 1-6 alkyl, unsubstituted or substituted aryl, unsubstituted or substituted arylalkyl. The present invention also relates to amorphous form of mitiglinide calcium, its preparation and process for its conversion to crystalline mitiglinide calcium. |
申请公布号 |
WO2009047797(A2) |
申请公布日期 |
2009.04.16 |
申请号 |
WO2008IN00645 |
申请日期 |
2008.10.07 |
申请人 |
IND-SWIFT LABORATORIES LIMITED;SARIN, GURDEEP, SINGH;SRINIVASAN, CHIDAMBARAM, VENKATESWARAN;WADHWA, LALIT |
发明人 |
SARIN, GURDEEP, SINGH;SRINIVASAN, CHIDAMBARAM, VENKATESWARAN;WADHWA, LALIT |
分类号 |
C07D209/44;C07D263/26;C07D413/06 |
主分类号 |
C07D209/44 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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