SUBSTITUTED INDAZOLES, THE PREPARATION THEREOF, AND USE OF SAME IN THERAPEUTICS

摘要

The invention relates to compounds of formula (I) wherein: E is a grouping (i) of formula -NT-CO-O- or -NT-CX-NT'- wherein X is =O or =S and T and T', that can be identical or different and selected independently, from H or an alkyl group, or (ii) forming a five-membered or six-membered ring bound in position 5 or 6 of the indazole nucleus by -NT- or by the nitrogen atom N1; R1 is at least one substituent selected independently when there are several, and being a halogen atom, an alkyl, alkenyl, alkynyl, halogenoalkyl, halogenoalcoxy, aryl, heteroaryl, heterocycloalkyl, cycloalkyl, CN, NRR', OR, NO2, COOR, CONRR', or NRCOR' group; R2 is a hydrogen atom, or an alkyl, alkenyl or alkynyl group; R3 is at least one substituent selected independently when there are several, and being a hydrogen atom, an alkyl, alkenyl, alkynyl, halogenoalcoxy, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN, NRR', CF3, OR, NO2, COOR, CONRR', or NRCOR' group; R4 is a hydrogen atom or a halogen atom, an alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocycloalkyl, -NR-CO-R', COOR, NRR', CHO, or CONR(OR') group; R and R' are identical or different and are independently a hydrogen atom, or an alkyl, aryl, heterocycloalkyl, cycloalkyl or heteroaryl group; and n1 is a whole number between 0 and 5, and n3 is a whole number between 0 and 3.