MetAP crystalline structures are disclosed. Also disclosed are inhibitors of bacterial methionine aminopeptidases, useful in treating bacterial infections and methods of identifying inhibitors of this aminopepticlase and methods of inhibiting MetAP using inhibitors with certain structural and spatial characteristics.
申请公布号
WO2005016237(A3)
申请公布日期
2009.04.16
申请号
WO2004US14258
申请日期
2004.05.07
申请人
SMITHKLINE BEECHAM CORPORATION;PALMER, LESLIE, M.;JANSON, CHERYL, A.;SMITH, WARD, WHITLOCK, JR.
发明人
PALMER, LESLIE, M.;JANSON, CHERYL, A.;SMITH, WARD, WHITLOCK, JR.