发明名称 |
RETINOIDS AND SMALL MOLECULES AS NRF2 ANTAGONISTS FOR USE IN THE TREATMENT OF DISEASES ASSOCIATED WITH ABNORMAL CELL PROLIFERATION |
摘要 |
The present invention relates to an improved assay for identifying compounds that may be of use in conjunction with cancer chemotherapeutic agents and anti-proliferative agents, to improve efficacy of such agents and/or render effective compounds with relatively little therapeutic activity. There is also provided a class of compounds of formula (I) and retinoids identified by said assay which may be used in a combination therapy, with current and novel agents, to treat cancers and other diseases associated with abnormal host cell proliferation, such as psoriasis. |
申请公布号 |
EP2046308(A2) |
申请公布日期 |
2009.04.15 |
申请号 |
EP20070789060 |
申请日期 |
2007.07.25 |
申请人 |
THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE |
发明人 |
WOLF, ROLAND;HAYES, JOHN;WANG, XIU, JUN |
分类号 |
A61K31/00;A61K31/07;A61K31/12;A61K31/203;A61P17/06;A61P35/00;C12N5/00;C12Q1/00 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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