| 摘要 |
The present invention provides a compound represented by Formula (II):
wherein R 1 is a chlorine atom, a fluorine atom, a methyl group or an ethynyl group;
Ar is a group represented by the following Formula (a), Formula (b), Formula (c) or Formula (d):
wherein R 2 is a C 1-6 alkyl group which may be substituted with one or more halogen atoms, a C 1-6 alkoxy group which may be substituted with one or more halogen atoms, a C 1-3 alkylthio group, a halogen atom, a C 1-3 alkylcarbonyl group or a C 2-5 alkynyl group which may be substituted with -OR 4 ;
R 3 is a hydrogen atom or a C 1-3 alkyl group;
R 4 is a hydrogen atom or a C 1-3 alkyl group;
provided that Ar is a group represented by Formula (a) when R 1 is a fluorine atom, methyl group or an ethynyl group, and
that R 2 is methoxy group, an ethoxy group, an isopropyl group, a propyl group, a trifluoromethyl group, a trifluoromethoxy group, 2-fluoroethyl group or 1-propynyl group when R 1 is a methyl group or a pharmaceutically acceptable salt or a solvate thereof and a pharmaceutical agent, a pharmaceutical composition and so on comprising the compound.
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