| 摘要 |
The present invention relates to industrially useful production processes
in which (±)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-ones and further (±)-3a,6,6,9a-tetramethyldo decahydronapbtho[2,1-b]furans are produced from raw materials which are readily available at low costs, through short steps and in a simple manner. The process for producing (±)-3a,6,6,9a-tetramethyldecahydronaphtho[2,1-b]furan-2(1H)-ones represented by the general formula (III):
which includes the steps of cyclizing a homofarnesylic acid amide represented by the general formula (I):
wherein R 1 and R 2 are each independently an alkyl group having 1 to 4 carbon atoms; and wavy lines each represents a carbon-to-carbon single bond having a cis or trans structure,
and/or a monocyclohomofarnesylic acid amide represented by the general formula (II):
wherein R 1 and R 2 and wavy lines are the same as defined above; and dotted lines represent that a carbon-to-carbon double bond is present at any of positions represented by the dotted lines,
in the presence off an acid agent; and subjecting the cyclized product to hydrolysis.
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