发明名称 |
MICROBUBBLES AS DRUG DELIVERY DEVICE |
摘要 |
A method of making PVA microbubbles including a functionalisation step in which PVA polymeric chains are functionalised at their ends with aldehyde groups, and a subsequent cross-linking step, in which in an air-aqueous solution emulsion with a pH between 4.5 and 5.5 the previously functionalised PVA polymeric chains cross-link by means of an acetalisation reaction, thereby forming the microbubbles. The microbubbles produced are subsequently subjected to a lyophilising step, a filling step in which medicinal gas is introduced and a restoration step of the microbubbles by adding an aqueous solution. |
申请公布号 |
EP2046395(A1) |
申请公布日期 |
2009.04.15 |
申请号 |
EP20070801507 |
申请日期 |
2007.08.03 |
申请人 |
PARADOSSI, GAIO;CAVALIERI, FRANCESCA |
发明人 |
PARADOSSI, GAIO;CAVALIERI, FRANCESCA |
分类号 |
A61K49/00;A61K9/50;C08F8/28 |
主分类号 |
A61K49/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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