| 发明名称 |
AN ANTI-CD137 ANTIBODY AS AN AGENT IN THE TREATEMENT OF CANCER AND GLYCOSYLATION VARIANTS THEREOF |
| 摘要 |
<p>The current invention relates to the development and methods of use of a recombinant agonistic antibody anti-human CD 137, and glycosylation variants thereof. These antibodies act as an anti-cancer agents and/or immune modulators that are effective in shrinking solid tumors or other cancerous indications and preventing their recurrence. The types of cancer for which the contemplated antibody is effective in treating also include leukemia and lymphoma. In a preferred embodiment the recombinant antibodies of the current invention were produced in and purified from the milk of transgenic animals.</p> |
| 申请公布号 |
EP1851244(A4) |
申请公布日期 |
2009.04.15 |
| 申请号 |
EP20050723079 |
申请日期 |
2005.02.15 |
| 申请人 |
GTC BIOTHERAPEUTICS, INC. |
发明人 |
STROME, SCOTT, E.;SCHINDLER, DANIEL;CHEN, LIEPING;MEADE, HARRY |
| 分类号 |
C07K16/00;A61K39/395;C12P21/00 |
主分类号 |
C07K16/00 |
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