MAKERS FOR THE DIAGNOSIS OF PROGNOSIS OF RHEUMATOID ARTHRITIS USING DNMT3B GENE AND METHOD FOR PREDICTING SEVERITY AND ANALYZING PROGNOSIS OF RHEUMATOID ARTHRITIS USING THE SAME

摘要

A maker for diagnosing the prognosis of rheumatoid arthritis by using DNMT3B(DNA-methyltransferase-3B) gene is provided to diagnose patients with severe rheumatoid arthritis by finding a genotype with high danger of articulation breakdown for rheumatoid arthritis. A maker for diagnosing the prognosis of rheumatoid arthritis comprises polynucleotides including 10-200 successive nucleotides containing the 548th base of a DNMT3B gene of the sequence number 1 or polynucleotides complementary with the polynucleotides. The 548th base of a DNMT3B gene of the sequence number 1 is selected from the genotype consisting of CC, CT and TT.