发明名称 |
AGENT FOR INJECTION PURPOSES COMPRISING ANTIBIOTIC, AND SOLUTION FOR INJECTION COMPRISING THE AGENT |
摘要 |
A pharmaceutical composition for injection comprising a depsipeptide antibiotic, WAP-8294A 2 , as an active ingredient, which is stable and contains WAP-8294A 2 in high concentrations is provided. This composition comprises WAP-8294A 2 of the following structural formula (1) as an active ingredient and is characterized in that 2-hydroxypropyl-²-cyclodextrin or ²-cyclodextrin is contained as a stabilizer or solubilizer and the pH of the composition is not adjusted. This composition is mixed with a pH-adjusting agent such as dextrose and with an infusion or diluent comprising a solution of disodium hydrogen phosphate, sodium dihydrogen phosphate, and sodium hydroxide at the time of use to prepare a solution for intravenous administration of WAP-8294A 2 .
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申请公布号 |
EP2047857(A1) |
申请公布日期 |
2009.04.15 |
申请号 |
EP20070767796 |
申请日期 |
2007.06.28 |
申请人 |
ARIGEN, PHARMACEUTICALS, INC. |
发明人 |
NAKAJIMA, HIROFUMI;MACHIDA, HARUHIKO |
分类号 |
A61K38/00;A61K9/08;A61K47/04;A61K47/26;A61K47/40;A61P31/04 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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