| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention relates to fields of molecular biology, virology, immunology and medicine. Composition contains modified virus-like particle (VLP), immuno-stimulating substances, in particular, DNA-oligonucleotides, containing non-methylated C and G (CpG), and separate peptides, obtained from MelanA. Said CpG-VLP are considerably more immunogenic than their analogues, which do not contain CpG, and induce enforced B- and T-cell responses. Immune response against analogues of peptide MelanA, conjugated with VLP, is enforced in the same way as immune response against VLP itself. In addition, T-cell responses against peptide MelanA analogues are mainly directed to type Th1. Antigens, associated with VLP, loaded with CpG, can be ideal vaccines against allergy, tumors and other autologic molecules and chronic viral diseases. ^ EFFECT: invention can be used in medicine. ^ 52 cl, 6 dwg, 4 tbl, 27 ex |
