| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention refers to method of producing 3-fluorine-containing quinolines of general formula (I): where R1, R2, R3 and R4, being identical or different, represent: - hydrogen; - fluorine atom; - group OR6 where R6 represents hydrogen atom, or linear or branched alkyl radical, characterised that compound of general formula (IV): where R1, R2, R3 and R4 possess values specified above, is exposed to Hofmann degradation enabled with sodium hydroxide and bromine, and pyridine in water at temperature about 60C to produce compound of general formula (III): where R1, R2, R3 and R4 possess values specified above, processed by alkali salt or alkyl ester of nitrous acid and fluoroboric acid or complex boron trifluoride and ethyl ether in appropriate solvent medium at temperature within 15C to 20C, reduced in producing diazonium salt of general formula (II): where R1, R2, R3 and R4 possess values specified above, heated up in inert organic solvent medium at temperature within 35C to 120C to produce compound of formula (I). Additionally, the invention refers to compounds of general formula (II). ^ EFFECT: new method of producing compounds of formula (I) being intermediates in producing compounds with antibacterial activity. ^ 8 cl, 4 ex |
