发明名称 |
MINERALIZED THREE-DIMENSIONAL BONE CONSTRUCTS |
摘要 |
The present disclosure provides ex vivo-derived mineralized three-dimensional bone constructs. The bone constructs are obtained by culturing osteoblasts and osteoclast precursors under randomized gravity vector conditions. Preferably, the randomized gravity vector conditions are obtained using a low shear stress rotating bioreactor, such as a High Aspect Ratio Vessel (HARV) culture system. The bone constructs of the disclosure have utility in physiological studies of bone formation and bone function, in drug discovery, and in orthopedics. |
申请公布号 |
WO2007115123(A3) |
申请公布日期 |
2009.04.09 |
申请号 |
WO2007US65542 |
申请日期 |
2007.03.29 |
申请人 |
CLARKE, MARK;SUNDARESAN, ALAMELU;PELLIS, NEAL |
发明人 |
CLARKE, MARK;SUNDARESAN, ALAMELU;PELLIS, NEAL |
分类号 |
C12N5/077;G06F11/00 |
主分类号 |
C12N5/077 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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