发明名称 |
SYNTHESIS OF THE C1-C6 KETO-ACID SYNTHON OF THE EPOTHILONES |
摘要 |
The present invention relates to alternative methods for producing keto-acid synthons, which are useful for the synthesis of epothilones and analogs and derivatives thereof. A general method according to the present invention broadly comprises performing aldol condensation of a first aldehyde of a general formula: (I) with a carbonyl compound in the form of a ketone or a second aldehyde having a generalized formula: (II) thereby to form a first compound having a generalized formula : (III) and thereafter converting the first compound to a protected keto-`acid synthon of generalized formula: (IV) The present invention is also directed to chemical compounds useful in the synthesis of epothilones and analogs and derivatives thereof and to methods for forming each of these chemical compounds. |
申请公布号 |
WO2005054429(A3) |
申请公布日期 |
2009.04.09 |
申请号 |
WO2004US38811 |
申请日期 |
2004.11.19 |
申请人 |
THE UNIVERSITY OF MISSISSIPPI;AVERY, MITCHELL, A.;ZHENG, YANSONG |
发明人 |
AVERY, MITCHELL, A.;ZHENG, YANSONG |
分类号 |
C07D493/04;C07C45/66;C07C45/72;C07C49/17;C07C49/713;C07D317/26;C07D417/06;C12N |
主分类号 |
C07D493/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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