发明名称 |
Methods For Selective Targeting |
摘要 |
A selective targeting method is disclosed comprising contacting a library of ligands, particularly a peptide library, with an anti-target to allow the ligands to bind to the anti-target; separating the non-binding ligands from the anti-target bound ligands, contacting the non-binding anti-target ligands with a target allowing the unbound ligands to bind with the target to form a target-bound ligand complex; separating the target-bound ligand complex from ligands which do not bind to the target, and identifying the target-bound ligands on the target-bound ligand complex wherein the target-bound ligands have a KD in the range of about 10-7 to 10-10 M. Additionally claimed are the ligands identified according to the method.
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申请公布号 |
US2009093393(A1) |
申请公布日期 |
2009.04.09 |
申请号 |
US20080099632 |
申请日期 |
2008.04.08 |
申请人 |
MURRAY CHRISTOPHER J;TIJERINA PILAR;ESTELL DAVID A;CHEN YIYOU |
发明人 |
MURRAY CHRISTOPHER J.;TIJERINA PILAR;ESTELL DAVID A.;CHEN YIYOU |
分类号 |
C11D1/10;G01N33/50;A61K38/00;A61P19/02;A61P29/00;A61P35/00;C07K7/00;C07K7/06;C07K7/08;C07K14/00;C12N15/09;C12N15/10;C12Q1/68;C40B30/04;C40B40/02;G01N33/15;G01N33/53;G01N33/566 |
主分类号 |
C11D1/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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