VARIANTS OF PROLACTIN AS ANTAGONISTS OF ITS RECEPTOR

摘要

The invention relates to mammalian prolactin (PRL) variants having a mutation within binding site 2 of PRL, wherein said mutation consists of a substitution of the glycine residue at position 129 (Gly129) with any amino acid, with the exception of arginine and proline. These variants are useful as antagonists of mammalian prolactin receptors (PRLR), more particularly of human prolactin receptor (hPRLR).