AGENTS THAT INHIBIT P-TEFB INTERACTIONS AND METHODS OF USE THEREOF

摘要

The present invention provides methods of treating disorders associated with abnormal cellular growth and/or proliferation. The methods generally involve administering an agent that reduces interaction of BRD4 with P-TEFb. The present invention further provides methods of treating an immunodeficiency virus infection. The methods generally involve administering an agent that reduces interaction of BRD4 with P-TEFb and/or a viral protein. The present invention further provides methods of identifying an agent that reduces binding of BRD4 with P-TEFb. The present invention further provides BRD4 peptides and recombinant BRD4 polypeptides.