OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING

摘要

Disclosed are a novel oxazolidinone derivative represented by the formula (I), a pharmaceutically acceptable salt thereof, and a solvate of the derivative or the pharmaceutically acceptable salt, which are useful as antibacterial agents. (I) wherein the ring A represents (A-1) a 7-membered monocyclic hetero ring having three N atoms, (A-2) a 7-membered monocyclic hetero ring having two N atoms and one O atom, or (A-3) a 7-membered monocyclic hetero ring having two N atoms and one S atom, SO or SO2, in which the monocyclic hetero ring may be substituted, may have an unsaturated bond, and may be fused with another ring; X1 represents a single bond, a hetero atom-containing group selected from the group consisting of -O-, -S-, -NR2-, -CO-, -CS-, -CONR3-, -NR4CO-, -SO2NR5- and -NR6SO2- [wherein R2 to R6 independently represent a hydrogen or a lower alkyl group], or a lower alkylene or alkenylene which may have the hetero atom-containing group therein; the ring B represents a carbon ring which may be substituted or a hetero ring which may be substituted; and R1 represents a hydrogen or an organic residue which can bind to position-5 in an oxazolidinone ring in an oxazolidinone antibacterial agent.