| 发明名称 |
Hyaluronic Acid-Methotrexate Conjugate |
| 摘要 |
An object of the present invention is to provide a hyaluronic acid-methotrexate conjugate useful as a therapeutic drug for joint disorders. There is provided a hyaluronic acid-methotrexate conjugate useful for the treatment of joint disorders, wherein methotrexate is conjugated with a hydroxy group of hyaluronic acid through a linker containing a peptide chain consisting of 1 to 8 amino acids, and the linker is conjugated with the hyaluronic acid through a carbamate group.
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| 申请公布号 |
US2009093414(A1) |
申请公布日期 |
2009.04.09 |
| 申请号 |
US20050547158 |
申请日期 |
2005.04.01 |
| 申请人 |
DENKI KAGAKU KOGYO KABUSHIKI KAISHA |
发明人 |
IKEYA HITOSHI;MORIKAWA TADASHI;TAKAHASHI KOICHI;IZUTANI NORIYUKI;TAMURA TATSUYA;OKAMACHI AKIRA;ISHIZAWA TAKENORI;SATO HARUHIKO;HIGUCHI YOSHINOBU;KATO TATSUYA;HONMA AKIE |
| 分类号 |
A61K31/728;A61K31/519;A61K38/03;A61K47/48;A61P19/02;C07D475/00;C07D475/08;C07D475/10;C07H3/00;C07K2/00;C07K5/00;C08B37/08 |
主分类号 |
A61K31/728 |
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