| 摘要 |
<p>Process for preparation of Ropivacaine hydrochloride monohydrate comprising resolution of racemic pipecoloxylidide in non-ketonic solvents to give (S)-pipecoloxylidide followed by N-propylation to in water ass reaction medium give (S)-Ropivacaine base; converting the said (S)-Ropivacaine base to (S)-Ropivacaine hydrochloride monohydrate in one step and recrystallizing the same from isopropanol. The non-ketonic etheric solvents used are preferably water-soluble cyclic ethers selected from tetrahydrofuran and 1,4-dioxan.</p> |
