| 摘要 |
PROBLEM TO BE SOLVED: To provide a compound useful as a beneficial medicine having the biological activity of natural lipoxins and a longer in vivo half-life by solving problems that lipoxin compounds are small molecules useful for the in vivo administration to a plurality of diseases and conditions at the sacrifice of short life in vivo. SOLUTION: This invention provides lipoxin analogs having an active region that is the same or similar to natural lipoxin and a metabolic transformation region which is more resistant to in vivo catabolism. The lipoxin analogs therefore have the biological activity of natural lipoxins, but a longer metabolic half-life. Certain of the disclosed lipoxin analogs may additionally have increased in vivo strength, higher binding affinity to lipoxin receptors or enhanced bioactivity as compared to natural lipoxins. COPYRIGHT: (C)2009,JPO&INPIT
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